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Project details:
Contractual authority:
UEFISCDI
Project type and number:
COMPEX EXPLORATORY RESEARCH PROJECTS - 2008
PCCE 248/2010
Project title:
"New concepts and strategies for the development of knowledge of new biocompatible structures in bioengineering".
Project leader:
Prof. PhD. Marieta Costache
Research teams and their respective coordinators:
P1 - Coordinating Institution:
UNIVERSITY OF BUCHAREST
DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
Prof. PhD. COSTACHE Marieta
P2 - INSTITUTE OF CELLULAR BIOLOGY AND PATHOLOGY "NICOLAE
SIMIONESCU" - BUCHAREST
LABORATORY FOR STEM CELLS AND CELLULAR THERAPY
Acad. PhD. SIMIONESCU Maya
P3 - UNIVERSITY POLITEHNICA OF BUCHAREST
FACULTY OF APPLIED CHEMISTRY AND MATERIAL SCIENCE
Prof. PhD. Eng. IOVU Horia
P4 - UNIVERSITY POLITEHNICA OF BUCHAREST
NATIONAL CONSULTANCY CENTER OF ENVIRONMENTAL PROTECTION
Prof. PhD. DEMETRESCU Ioana
P5 - INSTITUTE OF PHYSICAL CHEMISTRY "ILIE MURGULESCU" - BUCHAREST
PhD. POPA Mihai Vasile
P6 - BABES BOLYAI UNIVERSITY - CLUJ - NAPOCA
BIOMATERIALS CENTER - INSTITUTE FOR EXPERIMENTAL INTERDISCIPLINARY RESEARCH
Prof. PhD. SIMON Viorica
P7 - NATIONAL RESEARCH AND DEVELOPMENT INSTITUTE FOR CHEMISTRY
AND PETROCHEMISTRY - BUCHAREST
PhD. Eng. DIMONIE Doina
UEFISCDI
Project type and number:
COMPEX EXPLORATORY RESEARCH PROJECTS - 2008
PCCE 248/2010
Project title:
"New concepts and strategies for the development of knowledge of new biocompatible structures in bioengineering".
Project leader:
Prof. PhD. Marieta Costache
Research teams and their respective coordinators:
P1 - Coordinating Institution:
UNIVERSITY OF BUCHAREST
DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
Prof. PhD. COSTACHE Marieta
P2 - INSTITUTE OF CELLULAR BIOLOGY AND PATHOLOGY "NICOLAE
SIMIONESCU" - BUCHAREST
LABORATORY FOR STEM CELLS AND CELLULAR THERAPY
Acad. PhD. SIMIONESCU Maya
P3 - UNIVERSITY POLITEHNICA OF BUCHAREST
FACULTY OF APPLIED CHEMISTRY AND MATERIAL SCIENCE
Prof. PhD. Eng. IOVU Horia
P4 - UNIVERSITY POLITEHNICA OF BUCHAREST
NATIONAL CONSULTANCY CENTER OF ENVIRONMENTAL PROTECTION
Prof. PhD. DEMETRESCU Ioana
P5 - INSTITUTE OF PHYSICAL CHEMISTRY "ILIE MURGULESCU" - BUCHAREST
PhD. POPA Mihai Vasile
P6 - BABES BOLYAI UNIVERSITY - CLUJ - NAPOCA
BIOMATERIALS CENTER - INSTITUTE FOR EXPERIMENTAL INTERDISCIPLINARY RESEARCH
Prof. PhD. SIMON Viorica
P7 - NATIONAL RESEARCH AND DEVELOPMENT INSTITUTE FOR CHEMISTRY
AND PETROCHEMISTRY - BUCHAREST
PhD. Eng. DIMONIE Doina
Summary:
In tissue engineering (TE) the combined
knowledge from biology and engineering is directed towards the possibility to
restore lost or damaged tissue. The general aim of this project is to
consolidate a cross-disciplinary team of collaborating investigators to carry
out some cell-support constructs (CSC) with possible applications in
regeneration/repair of soft and hard tissues and it does not assume
pre-clinical and clinical trials. This application contains three specific
objectives:
1. Obtainment of new support 3-d structures designed to cultivate osteoblasts and human mesenchymal stem cells (hMSC) to obtain CSCs with characterized architecture and mechanical properties, useful in bone tissue engineering;
2. Development of regeneration strategies of adipose tissue by implantation of preadipocytes in 3-d hydrogel scaffolds, that mimic extracellular matrix, destined to the reconstruction of soft tissue defects (severe traumas, deep burns or tumor resections)
3. Study of the effects of 3-D culture and growth factors on the chondrogenic differentiation of hMSC cells to obtain some investigation models of their potential in cartilage tissue regeneration.
The project presents viability, innovation, complexity and interdisciplinary exchange because:
1. It is a consortium which consists from partners with complementally competences who engage to act as a unity in the following fields: cellular and molecular biology, chemistry and physics of materials, engineering sciences – in order to get all objectives;
2. The partners are staffs with a good, strong reputation on their field, and they have the necessary managerial experience as well as the human resources and performing equipment
3. The partnership was partially consolidated during previous collaborations and which sustain it. Accomplishment of the objectives of this project constitutes a scientific challenge for any scientific team around the world.
1. Obtainment of new support 3-d structures designed to cultivate osteoblasts and human mesenchymal stem cells (hMSC) to obtain CSCs with characterized architecture and mechanical properties, useful in bone tissue engineering;
2. Development of regeneration strategies of adipose tissue by implantation of preadipocytes in 3-d hydrogel scaffolds, that mimic extracellular matrix, destined to the reconstruction of soft tissue defects (severe traumas, deep burns or tumor resections)
3. Study of the effects of 3-D culture and growth factors on the chondrogenic differentiation of hMSC cells to obtain some investigation models of their potential in cartilage tissue regeneration.
The project presents viability, innovation, complexity and interdisciplinary exchange because:
1. It is a consortium which consists from partners with complementally competences who engage to act as a unity in the following fields: cellular and molecular biology, chemistry and physics of materials, engineering sciences – in order to get all objectives;
2. The partners are staffs with a good, strong reputation on their field, and they have the necessary managerial experience as well as the human resources and performing equipment
3. The partnership was partially consolidated during previous collaborations and which sustain it. Accomplishment of the objectives of this project constitutes a scientific challenge for any scientific team around the world.
Key words:
- human Mesenchimal Stem Cells (hMSC)
- adipose derived stem cells (ADAS)
- osteoblastes
- adipocytes
- chondrocytes
- hybrid polymeric compositions
- inorganic nanostructured scaffolds
- metalic alloys
- regenerative medicine
- tissue engineering
- bioengineering
- adipose derived stem cells (ADAS)
- osteoblastes
- adipocytes
- chondrocytes
- hybrid polymeric compositions
- inorganic nanostructured scaffolds
- metalic alloys
- regenerative medicine
- tissue engineering
- bioengineering
Publications:
Results:
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